Glycine receptor antibodies in stiff-person syndrome and other GAD-positive CNS disorders.
نویسندگان
چکیده
published online October 30, 2013 Neurology Harry Alexopoulos, Sofia Akrivou and Marinos C. Dalakas GAD-positive CNS disorders Glycine receptor antibodies in stiff-person syndrome and other This information is current as of October 30, 2013 html http://www.neurology.org/content/early/2013/10/30/01.wnl.0000436617.40779.65.full. located on the World Wide Web at: The online version of this article, along with updated information and services, is
منابع مشابه
P102: The Association of the Anti-GAD Antibodies to the Neurological Conditions
Glutamic acid decarboxylase (GAD) is an enzyme which converts the glutamic acid to the neurotransmitter gamma-amino butyric acid (GABA). GABA is an inhibitory neurotransmitter that inhibits or weakens the neuronal stimulations. Presynaptic GABAergic neurons in the central neurons system (CNS) and the cells in the islets of Langerhans in the pancreas generate GAD. There are two isoforms of GAD n...
متن کاملClinical Spectrum of Stiff Person Syndrome: A Review of Recent Reports
BACKGROUND "Classic" stiff person syndrome (SPS) features stiffness, anti-glutamic acid decarboxylase (anti-GAD) antibodies, and other findings. Anti-GAD antibodies are also detected in some neurological syndromes (such as ataxia) in which stiffness is inconsistently present. Patients with otherwise "classic" SPS may either lack anti-GAD antibodies or be seropositive for others. Hence, SPS case...
متن کاملNeurological disorders associated with glutamic acid decarboxylase antibodies: a Brazilian series Distúrbios neurológicos associadas a anticorpos anti-GAD (descarboxilase do ácido glutâmico): uma série de casos brasileira
Neurological disorders associated with glutamic acid decarboxylase (GAD) antibodies include stiff-person syndrome (SPS) and its variants — stiff trunk syndrome, stiff limbs syndrome, progressive encephalomyelitis with rigidity, SPS-plus and paraneoplastic SPS — as well as epilepsy and ataxia1-8. These syndromes are often found in association with other autoimmune disorders, such as diabetes mel...
متن کاملP159: New Findings in The Diagnosis of Autoimmune Diseases of the Nervous System
The antibody of the nervous system is called antibodies that the body makes to the nervous system cells. These antibodies are also very diverse based on the complexity and diversity of the nervous system, and therefore their detection is also associated with particular challenges. Generally, autoimmune diseases are on the rise. The diagnostic techniques for autoimmune diseases are also in progr...
متن کاملHuman Stiff-Person Syndrome IgG Induces Anxious Behavior in Rats
BACKGROUND Anxiety is a heterogeneous behavioral domain playing a role in a variety of neuropsychiatric diseases. While anxiety is the cardinal symptom in disorders such as panic disorder, co-morbid anxious behavior can occur in a variety of diseases. Stiff person syndrome (SPS) is a CNS disorder characterized by increased muscle tone and prominent agoraphobia and anxiety. Most patients have hi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neurology
دوره 81 22 شماره
صفحات -
تاریخ انتشار 2013